Antifibrinolytic therapy in genitourinary tract surgery

Antifibrinolytic therapy in genitourinary tract surgery.

Severe generalised haemorrhage associated with plasma proteolytic activity after thoracic surgery, operations for hyperplasia or carcinoma of the prostate, gastrointestinal or pancreatic resection, and other operations was reported in the early 1950s.1-3 Such plasma proteolytic activity is usually part of a disseminated intravascular coagulation syndrome. Sometimes, however, the local fibrinoly...

Basis of antifibrinolytic therapy.

The coagulation and fibrinolytic enzyme systems oppose each other in the haemostatic process. Coagulation occurs, of necessity, rapidly and explosively so that a site of vessel damage causing blood loss can be rapidly sealed. The fibrinolytic process, on the other hand, serves as a repair system to remove fibrin deposits which might otherwise cause permanent vascular occlusion. This must occur ...

Genitourinary and Renal Tract Disorders

The Safety and Efficacy of Antifibrinolytic Therapy in Neonatal Cardiac Surgery

BACKGROUND Neonates undergoing open-heart surgery are particularly at risk of postoperative bleeding requiring blood transfusion. Aprotinin has attained high efficacy in reducing the requirement for a blood transfusion following a cardiopulmonary bypass, but is seldom studied in the neonatal age group. The aim of this study was to compare the efficacy and adverse effects of aprotinin and tranex...

Antifibrinolytic therapy and perioperative blood loss in cancer patients undergoing major orthopedic surgery.

BACKGROUND Aprotinin has been reported to reduce blood loss and transfusion requirements in patients having major orthopedic operations. Data on whether epsilon amino-caproic acid (EACA) is effective in this population are sparse. METHODS Sixty-nine adults with malignancy scheduled for either pelvic, extremity or spine surgery during general anesthesia entered this randomized, double-blind, p...